Anti Estrogen Steroids Fulvestrant 129453-61-8 with 99% Purity for
Fulvestrant is known as a hormonal breast cancer treatment. It is
used to treat advanced breast cancer and metastatic breast cancer.
Advanced breast cancer is cancer which has progressed despite
treatment, and metastatic breast cancer is cancer which has spread
into other parts of the body.
Many breast cancers need the female hormone oestrogen to grow. The
cells of these cancers have tiny areas called receptors on their
surface, which oestrogen can attach to. They are called 'hormone
receptor-positive' cancers. Fulvestrant works by blocking the
receptors and this prevents oestrogen from reaching the cancer
cells. This slows the growth of the cancer.
Chemical Names: Fulvestrant; Faslodex; 129453-61-8; ICI 182,780;
Ici 182780; ICI-182780 More...
Molecular Formula: C32H47F5O3S
Molecular Weight: 606.777 g/mol
Boiling Point: 674.8 °C at 760 mmHg
Appearance: white powder
Storage condition: 2-8°C
Usage: Antineoplastic (hormonal)
Fulvestrant is used to treat breast cancer that has spread to other
areas of the body in women who have gone through "the change of
life" (menopause). It is used in patients who have not responded
well to other medications (e.g., tamoxifen). Breast cancer cells
need the hormone estrogen in order to grow. Fulvestrant works by
blocking the effect of estrogen, slowing tumor cell growth.
How Fulvestrant Works:
Many breast cancers are stimulated to grow by the female sex
hormones oestrogen and progesterone. These breast cancers are
called hormone sensitive or hormone receptor positive. Drugs that
block the effects of these hormones can slow or stop the growth of
the breast cancer cells. Fulvestrant stops oestrogen getting to the
cancer cells by blocking oestrogen receptors and reducing the
number of receptors the cancer cells have.
What are the possible side effects of fulvestrant (Faslodex)?
Get emergency medical help if you have any of these signs of an
allergic reaction: hives; difficult breathing; swelling of your
face, lips, tongue, or throat.
Less serious side effects may include:
headache, back pain;
bone pain, joint pain, muscle pain;
vomiting, loss of appetite, constipation;
weakness, feeling tired;
cough, trouble breathing;
pain in your arms or legs;
hot flashes; or
pain where the medicine was injected.
Before taking fulvestrant:
tell your doctor and pharmacist if you are allergic to fulvestrant
or any other medications.
tell your doctor and pharmacist what prescription and
nonprescription medications, vitamins, nutritional supplements, and
herbal products you are taking or plan to take. Be sure to mention
anticoagulants (blood thinners) such as warfarin (Coumadin). Your
doctor may need to change the doses of your medications or monitor
you carefully for side effects.
tell your doctor if you have or have ever had any bleeding problems
or liver disease.
you should know that fulvestrant should only be taken by women who
have undergone menopause and cannot become pregnant. However, if
you are pregnant, you should tell your doctor before you begin
treatment with this medication. Your doctor may also check to see
if you are pregnant before you begin treatment. Tell your doctor if
you become pregnant during your treatment with fulvestrant.
Fulvestrant may harm the fetus.
tell your doctor if you are breast-feeding. You should not
breast-feed during your treatment with fulvestrant.
How this drug is given:
As an injection into the muscle (intramuscular, IM).
Fulvestrant is usually given as a once a month injection. Your
doctor will determine any variations to this dosing or schedule.
Usual Adult Dose for Breast Cancer:
Initial dose: 500 mg IM on days 1, 15, and 29, then once a month
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